Drug interactions
Fluticasone-salmeterol + Idelalisib
Severity: Major
Fluticasone-salmeterol and Idelalisib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can substantially raise salmeterol and fluticasone exposure. This increases the risk of tachycardia, QT prolongation and systemic corticosteroid effects.
What this interaction means in plain words
Fluticasone-salmeterol and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-salmeterol belongs to Respiratory; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition decreasing clearance of salmeterol and fluticasone.
What to do
Avoid the combination and consider beclomethasone as the inhaled corticosteroid and a non-CYP3A4-dependent bronchodilator. If used together, monitor ECG and for Cushingoid effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Zydelig 100 mg Film-coated Tablets - SmPC sections 4.3/4.5 (names the partner; "Inhaled/nasal corticosteroids: Budesonide, fluticasone") — electronic medicines compendium (UK SmPC)
Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Idelalisib?
MediHelp rates the interaction as major. Fluticasone-salmeterol and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor and can substantially raise salmeterol and fluticasone exposure. This increases the risk of tachycardia, QT prolongation and systemic corticosteroid effects.
How serious is the interaction between Fluticasone-salmeterol and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider beclomethasone as the inhaled corticosteroid and a non-CYP3A4-dependent bronchodilator. If used together, monitor ECG and for Cushingoid effects.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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