Drug interactions
Fluticasone-salmeterol + Risperidone
Severity: Minor
Fluticasone-salmeterol and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause sedation, and salmeterol does not meaningfully counteract it. Risperidone prolongs the QT interval modestly and beta-agonists can add to QT and heart rate effects.
What this interaction means in plain words
Fluticasone-salmeterol and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-salmeterol belongs to Respiratory; Risperidone belongs to Central Nervous System.
Why it happens
Possible additive cardiac effects (QT, tachycardia); no established sedative interaction.
What to do
No routine action; consider ECG in patients with QT risk factors or cardiac disease using high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Risperidone?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Risperidone can cause sedation, and salmeterol does not meaningfully counteract it. Risperidone prolongs the QT interval modestly and beta-agonists can add to QT and heart rate effects.
How serious is the interaction between Fluticasone-salmeterol and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action; consider ECG in patients with QT risk factors or cardiac disease using high doses.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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