Drug interactions
Fluticasone-salmeterol + Rucaparib
Severity: Minor
Fluticasone-salmeterol and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak CYP3A4 inhibitor and may slightly raise salmeterol and fluticasone exposure. The effect is likely small with inhaled doses, but beta-agonist or corticosteroid adverse effects are possible.
What this interaction means in plain words
Fluticasone-salmeterol and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-salmeterol belongs to Respiratory; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 by rucaparib reduces the metabolism of salmeterol and fluticasone.
What to do
Watch for palpitations, tremor and tachycardia during concurrent use. Reduce the inhaled dose only if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Fluticasone-salmeterol with Rucaparib?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak CYP3A4 inhibitor and may slightly raise salmeterol and fluticasone exposure. The effect is likely small with inhaled doses, but beta-agonist or corticosteroid adverse effects are possible.
How serious is the interaction between Fluticasone-salmeterol and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for palpitations, tremor and tachycardia during concurrent use. Reduce the inhaled dose only if adverse effects occur.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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