Drug interactions
Fluticasone-salmeterol + Stiripentol
Severity: Minor
Fluticasone-salmeterol and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP3A4, so exposure to salmeterol and fluticasone may rise or fall unpredictably. The effect with inhaled doses is probably limited but could be relevant in sensitive patients.
What this interaction means in plain words
Fluticasone-salmeterol and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-salmeterol belongs to Respiratory; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed inhibition and induction of CYP3A4 by stiripentol alters the metabolism of salmeterol and fluticasone.
What to do
Monitor respiratory control and for beta-agonist or corticosteroid adverse effects when stiripentol is started or changed. Adjust the inhaled dose according to the observed response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Fluticasone-salmeterol with Stiripentol?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol has both inhibitory and inducing effects on CYP3A4, so exposure to salmeterol and fluticasone may rise or fall unpredictably. The effect with inhaled doses is probably limited but could be relevant in sensitive patients.
How serious is the interaction between Fluticasone-salmeterol and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory control and for beta-agonist or corticosteroid adverse effects when stiripentol is started or changed. Adjust the inhaled dose according to the observed response.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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