Drug interactions
Fluticasone-salmeterol + Trimipramine
Severity: Moderate
Fluticasone-salmeterol and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants like trimipramine can prolong QT and increase arrhythmia risk, and salmeterol can add to cardiovascular stimulation. Salmeterol labeling advises caution with tricyclics because vascular and cardiac effects of the beta-agonist may be potentiated.
What this interaction means in plain words
Fluticasone-salmeterol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Tricyclics potentiate adrenergic cardiovascular effects and prolong QT, additive with beta2-agonist effects.
What to do
Monitor heart rate, blood pressure and ECG in patients with cardiac risk, and avoid excess salmeterol dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Trimipramine?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants like trimipramine can prolong QT and increase arrhythmia risk, and salmeterol can add to cardiovascular stimulation. Salmeterol labeling advises caution with tricyclics because vascular and cardiac effects of the beta-agonist may be potentiated.
How serious is the interaction between Fluticasone-salmeterol and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG in patients with cardiac risk, and avoid excess salmeterol dosing.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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