Drug interactions
Fluticasone-salmeterol + Valbenazine
Severity: Moderate
Fluticasone-salmeterol and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine can prolong the QT interval at higher exposures, and salmeterol may also prolong QTc and cause tachycardia and hypokalemia. Together they may raise the risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Fluticasone-salmeterol and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QTc prolongation, with beta-2 mediated hypokalemia contributing.
What to do
Obtain an ECG and check potassium and magnesium in patients with cardiac disease or other QT-prolonging drugs. Correct electrolytes and reassess if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Valbenazine?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine can prolong the QT interval at higher exposures, and salmeterol may also prolong QTc and cause tachycardia and hypokalemia. Together they may raise the risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Fluticasone-salmeterol and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check potassium and magnesium in patients with cardiac disease or other QT-prolonging drugs. Correct electrolytes and reassess if QTc lengthens.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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