Drug interactions
Fluticasone-vilanterol + Furosemide
Severity: Moderate
Fluticasone-vilanterol and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide promotes urinary potassium loss and vilanterol can further reduce serum potassium via cellular uptake. Together they may cause hypokalemia and ECG changes, particularly in patients with cardiac disease.
What this interaction means in plain words
Fluticasone-vilanterol and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Furosemide belongs to Cardiovascular.
Why it happens
Additive hypokalemia from loop diuretic potassium wasting and beta2-mediated intracellular potassium shift.
What to do
Monitor serum potassium and magnesium and replace as needed, especially in patients with heart disease or on other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Furosemide?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide promotes urinary potassium loss and vilanterol can further reduce serum potassium via cellular uptake. Together they may cause hypokalemia and ECG changes, particularly in patients with cardiac disease.
How serious is the interaction between Fluticasone-vilanterol and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and replace as needed, especially in patients with heart disease or on other QT-prolonging drugs.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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