Drug interactions
Fluticasone-vilanterol + Gilteritinib
Severity: Moderate
Fluticasone-vilanterol and Gilteritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib can prolong the QT interval and cause arrhythmia. Vilanterol may add to this through beta2-agonist effects and hypokalemia, especially in patients who already have electrolyte disturbances.
What this interaction means in plain words
Fluticasone-vilanterol and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Gilteritinib belongs to Oncology.
Why it happens
Additive QT prolongation with beta2-agonist-related hypokalemia.
What to do
Monitor ECG and keep potassium and magnesium in the normal range. Follow gilteritinib labeling for dose adjustment if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Gilteritinib?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib can prolong the QT interval and cause arrhythmia. Vilanterol may add to this through beta2-agonist effects and hypokalemia, especially in patients who already have electrolyte disturbances.
How serious is the interaction between Fluticasone-vilanterol and Gilteritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium and magnesium in the normal range. Follow gilteritinib labeling for dose adjustment if QTc becomes prolonged.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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