Drug interactions
Fluticasone-vilanterol + Haloperidol
Severity: Moderate
Fluticasone-vilanterol and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol prolongs the QT interval and has been linked to torsades de pointes, particularly at high or intravenous doses. Vilanterol can add to this through adrenergic stimulation and hypokalemia.
What this interaction means in plain words
Fluticasone-vilanterol and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Haloperidol belongs to Central Nervous System.
Why it happens
Additive QTc prolongation via hERG blockade plus beta-agonist effects on potassium and heart rate.
What to do
Use the lowest effective haloperidol dose and monitor ECG and electrolytes in patients with cardiac risk factors. Avoid combining further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Haloperidol?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol prolongs the QT interval and has been linked to torsades de pointes, particularly at high or intravenous doses. Vilanterol can add to this through adrenergic stimulation and hypokalemia.
How serious is the interaction between Fluticasone-vilanterol and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective haloperidol dose and monitor ECG and electrolytes in patients with cardiac risk factors. Avoid combining further QT-prolonging drugs.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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