Drug interactions
Fluticasone-vilanterol + Itraconazole
Severity: Major
Fluticasone-vilanterol and Itraconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 inhibitor and raises exposure to both fluticasone furoate and vilanterol. This may increase corticosteroid systemic effects including adrenal suppression, and beta-agonist cardiovascular effects. Itraconazole also prolongs the QT interval.
What this interaction means in plain words
Fluticasone-vilanterol and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces clearance of both inhaled components, with additive QT effects.
What to do
Use with caution and monitor for cardiovascular effects, hypokalemia and QTc, and signs of systemic corticosteroid effects; consider an alternative antifungal or inhaler for prolonged use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluticasone-vilanterol
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Itraconazole?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole is a strong CYP3A4 inhibitor and raises exposure to both fluticasone furoate and vilanterol. This may increase corticosteroid systemic effects including adrenal suppression, and beta-agonist cardiovascular effects. Itraconazole also prolongs the QT interval.
How serious is the interaction between Fluticasone-vilanterol and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use with caution and monitor for cardiovascular effects, hypokalemia and QTc, and signs of systemic corticosteroid effects; consider an alternative antifungal or inhaler for prolonged use.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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