Drug interactions
Fluticasone-vilanterol + Lonafarnib
Severity: Major
Fluticasone-vilanterol and Lonafarnib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and can increase exposure to vilanterol and fluticasone furoate. This may heighten beta-agonist cardiovascular effects and systemic corticosteroid effects.
What this interaction means in plain words
Fluticasone-vilanterol and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Lonafarnib belongs to Miscellaneous.
Why it happens
Strong CYP3A inhibition reducing clearance of vilanterol and fluticasone furoate.
What to do
Avoid if possible; otherwise monitor heart rate, ECG, potassium and signs of corticosteroid excess. Consider an alternative inhaled regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Lonafarnib?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a strong CYP3A inhibitor and can increase exposure to vilanterol and fluticasone furoate. This may heighten beta-agonist cardiovascular effects and systemic corticosteroid effects.
How serious is the interaction between Fluticasone-vilanterol and Lonafarnib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor heart rate, ECG, potassium and signs of corticosteroid excess. Consider an alternative inhaled regimen.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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