Drug interactions
Fluticasone-vilanterol + Mefloquine
Severity: Moderate
Fluticasone-vilanterol and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can alter cardiac conduction and prolong QT, and vilanterol may add to arrhythmic risk. This is of most concern in patients with cardiac disease or electrolyte disturbance.
What this interaction means in plain words
Fluticasone-vilanterol and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive QTc prolongation with beta-agonist-induced hypokalemia.
What to do
Consider alternative antimalarial prophylaxis in patients with cardiac risk. If combined, monitor ECG and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Mefloquine?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can alter cardiac conduction and prolong QT, and vilanterol may add to arrhythmic risk. This is of most concern in patients with cardiac disease or electrolyte disturbance.
How serious is the interaction between Fluticasone-vilanterol and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider alternative antimalarial prophylaxis in patients with cardiac risk. If combined, monitor ECG and electrolytes.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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