Drug interactions
Fluticasone-vilanterol + Moxifloxacin
Severity: Moderate
Fluticasone-vilanterol and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin is among the fluoroquinolones with a notable QT-prolonging effect, and vilanterol may add to cardiac risk. Torsades de pointes is possible in susceptible patients.
What this interaction means in plain words
Fluticasone-vilanterol and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive QTc prolongation with beta-agonist adrenergic and hypokalemic effects.
What to do
Use a non-QT-prolonging antibiotic where possible. If combined, correct potassium and magnesium and monitor ECG in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Moxifloxacin?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxifloxacin is among the fluoroquinolones with a notable QT-prolonging effect, and vilanterol may add to cardiac risk. Torsades de pointes is possible in susceptible patients.
How serious is the interaction between Fluticasone-vilanterol and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging antibiotic where possible. If combined, correct potassium and magnesium and monitor ECG in at-risk patients.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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