Drug interactions
Fluticasone-vilanterol + Osimertinib
Severity: Moderate
Fluticasone-vilanterol and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QT interval, and vilanterol may add to cardiac effects and lower potassium. The combination may raise arrhythmia risk in patients with other risk factors.
What this interaction means in plain words
Fluticasone-vilanterol and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Osimertinib belongs to Oncology.
Why it happens
Additive QT prolongation with beta2-agonist-related hypokalemia.
What to do
Monitor ECG and electrolytes periodically and correct potassium and magnesium abnormalities. Follow osimertinib labeling for interruption if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Osimertinib
Frequently asked questions
Can I take Fluticasone-vilanterol with Osimertinib?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QT interval, and vilanterol may add to cardiac effects and lower potassium. The combination may raise arrhythmia risk in patients with other risk factors.
How serious is the interaction between Fluticasone-vilanterol and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes periodically and correct potassium and magnesium abnormalities. Follow osimertinib labeling for interruption if QTc becomes markedly prolonged.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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