Drug interactions
Fluticasone-vilanterol + Paliperidone
Severity: Moderate
Fluticasone-vilanterol and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone can prolong the QT interval and cause tachycardia, and vilanterol adds adrenergic cardiac effects. The risk is mainly relevant for patients with existing cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Fluticasone-vilanterol and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Paliperidone belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization and heart rate.
What to do
Check ECG and electrolytes in patients with cardiovascular risk factors and monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Paliperidone?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone can prolong the QT interval and cause tachycardia, and vilanterol adds adrenergic cardiac effects. The risk is mainly relevant for patients with existing cardiac disease or electrolyte disturbances.
How serious is the interaction between Fluticasone-vilanterol and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with cardiovascular risk factors and monitor for palpitations or syncope.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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