Drug interactions
Fluticasone-vilanterol + Ribociclib
Severity: Moderate
Fluticasone-vilanterol and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a CYP3A4 inhibitor that can increase exposure to vilanterol and fluticasone furoate, and it also prolongs the QT interval. This may increase beta-agonist cardiac effects and corticosteroid systemic effects.
What this interaction means in plain words
Fluticasone-vilanterol and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Ribociclib belongs to Oncology.
Why it happens
CYP3A4 inhibition raises vilanterol and fluticasone exposure, with additive QT effects.
What to do
Monitor ECG, electrolytes and heart rate, and watch for systemic corticosteroid effects during prolonged use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Ribociclib?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a CYP3A4 inhibitor that can increase exposure to vilanterol and fluticasone furoate, and it also prolongs the QT interval. This may increase beta-agonist cardiac effects and corticosteroid systemic effects.
How serious is the interaction between Fluticasone-vilanterol and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, electrolytes and heart rate, and watch for systemic corticosteroid effects during prolonged use.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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