Drug interactions
Fluticasone-vilanterol + Rilpivirine
Severity: Moderate
Fluticasone-vilanterol and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine at supratherapeutic doses prolongs the QTc interval, while vilanterol can influence heart rate and repolarization. At usual doses the additive effect is probably small but may matter in patients with other risk factors.
What this interaction means in plain words
Fluticasone-vilanterol and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Rilpivirine belongs to Anti Virals.
Why it happens
Possible additive QT prolongation.
What to do
Check ECG in patients with additional QT risk factors or heart disease. Correct low potassium or magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Rilpivirine?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine at supratherapeutic doses prolongs the QTc interval, while vilanterol can influence heart rate and repolarization. At usual doses the additive effect is probably small but may matter in patients with other risk factors.
How serious is the interaction between Fluticasone-vilanterol and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG in patients with additional QT risk factors or heart disease. Correct low potassium or magnesium.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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