Drug interactions
Fluticasone-vilanterol + Tacrolimus
Severity: Moderate
Fluticasone-vilanterol and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus has a recognized potential to prolong the QT interval and can cause hypokalemia and hypomagnesemia. Vilanterol may add to this through beta-2 mediated lowering of potassium and cardiac stimulation, although inhaled systemic exposure is small.
What this interaction means in plain words
Fluticasone-vilanterol and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive effects on cardiac repolarization and electrolyte disturbance.
What to do
Monitor ECG and serum potassium and magnesium, particularly in patients with other QT risk factors. Replace electrolytes as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Tacrolimus?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus has a recognized potential to prolong the QT interval and can cause hypokalemia and hypomagnesemia. Vilanterol may add to this through beta-2 mediated lowering of potassium and cardiac stimulation, although inhaled systemic exposure is small.
How serious is the interaction between Fluticasone-vilanterol and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium and magnesium, particularly in patients with other QT risk factors. Replace electrolytes as needed.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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