Drug interactions
Fluticasone-vilanterol + Tipranavir
Severity: Moderate
Fluticasone-vilanterol and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, strongly inhibits CYP3A4 and can markedly raise systemic fluticasone furoate and vilanterol levels. This may cause cardiovascular beta-agonist effects and corticosteroid effects such as adrenal suppression.
What this interaction means in plain words
Fluticasone-vilanterol and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4, reducing clearance of both inhaled components.
What to do
Monitor heart rate, potassium and QT-related symptoms, and watch for Cushingoid features or adrenal suppression; consider an alternative inhaled steroid such as beclomethasone for long-term use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Tipranavir?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, strongly inhibits CYP3A4 and can markedly raise systemic fluticasone furoate and vilanterol levels. This may cause cardiovascular beta-agonist effects and corticosteroid effects such as adrenal suppression.
How serious is the interaction between Fluticasone-vilanterol and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, potassium and QT-related symptoms, and watch for Cushingoid features or adrenal suppression; consider an alternative inhaled steroid such as beclomethasone for long-term use.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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