Drug interactions
Fluticasone-vilanterol + Vemurafenib
Severity: Moderate
Fluticasone-vilanterol and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QTc interval in a concentration-dependent way. Vilanterol may add to arrhythmic risk through adrenergic stimulation and hypokalemia.
What this interaction means in plain words
Fluticasone-vilanterol and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Check ECG and electrolytes at baseline and periodically during co-use. Correct electrolyte abnormalities and reassess therapy if QTc rises substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Vemurafenib
Frequently asked questions
Can I take Fluticasone-vilanterol with Vemurafenib?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib can prolong the QTc interval in a concentration-dependent way. Vilanterol may add to arrhythmic risk through adrenergic stimulation and hypokalemia.
How serious is the interaction between Fluticasone-vilanterol and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and periodically during co-use. Correct electrolyte abnormalities and reassess therapy if QTc rises substantially.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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