Drug interactions
Fluticasone-vilanterol + Voriconazole
Severity: Moderate
Fluticasone-vilanterol and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4, which raises exposure to both fluticasone furoate and vilanterol, and it can also prolong the QT interval. This may increase systemic corticosteroid effects, cardiac stimulation and arrhythmia risk.
What this interaction means in plain words
Fluticasone-vilanterol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Voriconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition raising exposure to both inhaled drugs, plus additive QT prolongation.
What to do
Monitor ECG, potassium and heart rate, and watch for systemic corticosteroid and beta-agonist adverse effects. Consider an alternative antifungal if long-term co-therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Voriconazole?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4, which raises exposure to both fluticasone furoate and vilanterol, and it can also prolong the QT interval. This may increase systemic corticosteroid effects, cardiac stimulation and arrhythmia risk.
How serious is the interaction between Fluticasone-vilanterol and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and heart rate, and watch for systemic corticosteroid and beta-agonist adverse effects. Consider an alternative antifungal if long-term co-therapy is needed.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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