Drug interactions
Fluticasone-vilanterol + Vorinostat
Severity: Moderate
Fluticasone-vilanterol and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can prolong the QT interval and raise heart rate. Vorinostat has been associated with QT changes, so combined use may add to the risk of arrhythmia, particularly with electrolyte disturbances.
What this interaction means in plain words
Fluticasone-vilanterol and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Vorinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and adrenergic cardiovascular stimulation.
What to do
Check baseline ECG and correct potassium and magnesium before starting. Monitor ECG and for palpitations in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Vorinostat?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can prolong the QT interval and raise heart rate. Vorinostat has been associated with QT changes, so combined use may add to the risk of arrhythmia, particularly with electrolyte disturbances.
How serious is the interaction between Fluticasone-vilanterol and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before starting. Monitor ECG and for palpitations in patients with cardiac risk factors.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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