Drug interactions
Fluvastatin + Fostamatinib
Severity: Moderate
Fluvastatin and Fostamatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits BCRP, and fluvastatin is partly a BCRP substrate. Fluvastatin exposure may increase, with greater risk of dose-related muscle effects.
What this interaction means in plain words
Fluvastatin and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Fostamatinib belongs to Oncology.
Why it happens
Inhibition of BCRP by the fostamatinib metabolite tamatinib increases fluvastatin absorption.
What to do
Monitor for myopathy and reduce the fluvastatin dose if adverse effects occur. Check creatine kinase if muscle symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Fluvastatin with Fostamatinib?
MediHelp rates the interaction as moderate. Fluvastatin and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite inhibits BCRP, and fluvastatin is partly a BCRP substrate. Fluvastatin exposure may increase, with greater risk of dose-related muscle effects.
How serious is the interaction between Fluvastatin and Fostamatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myopathy and reduce the fluvastatin dose if adverse effects occur. Check creatine kinase if muscle symptoms develop.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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