Drug interactions
Fluvastatin + Levoketoconazole
Severity: Minor
Fluvastatin and Levoketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvastatin is cleared mainly by CYP2C9, which is not strongly inhibited by levoketoconazole, so a large increase in exposure is unlikely. A small rise through transporter effects is possible.
What this interaction means in plain words
Fluvastatin and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Levoketoconazole belongs to Endocrine.
Why it happens
Possible weak inhibition of OATP1B1 or BCRP; CYP3A4 inhibition is not relevant to fluvastatin.
What to do
No routine dose change is needed. Monitor for muscle symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Fluvastatin with Levoketoconazole?
MediHelp rates the interaction as minor. Fluvastatin and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvastatin is cleared mainly by CYP2C9, which is not strongly inhibited by levoketoconazole, so a large increase in exposure is unlikely. A small rise through transporter effects is possible.
How serious is the interaction between Fluvastatin and Levoketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for muscle symptoms.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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