Drug interactions
Fluvastatin + Pretomanid
Severity: Minor
Fluvastatin and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits OATP1B3 in vitro, so substrates of this transporter may reach higher concentrations. Fluvastatin is mainly an OATP1B1 and 2B1 substrate, so any effect is likely small.
What this interaction means in plain words
Fluvastatin and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Why it happens
Possible inhibition of OATP-mediated hepatic uptake by pretomanid.
What to do
No dose change is usually needed; monitor for statin-related muscle symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Pretomanid
Frequently asked questions
Can I take Fluvastatin with Pretomanid?
MediHelp rates the interaction as minor. Fluvastatin and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits OATP1B3 in vitro, so substrates of this transporter may reach higher concentrations. Fluvastatin is mainly an OATP1B1 and 2B1 substrate, so any effect is likely small.
How serious is the interaction between Fluvastatin and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for statin-related muscle symptoms.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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