Drug interactions
Fluvastatin + Ranolazine
Severity: Minor
Fluvastatin and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine may raise statin exposure through transporter effects, which could increase the risk of muscle toxicity. Fluvastatin is mainly metabolized by CYP2C9, so the effect is probably small.
What this interaction means in plain words
Fluvastatin and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvastatin belongs to Cardiovascular; Ranolazine belongs to Cardiovascular.
Why it happens
Ranolazine may inhibit hepatic uptake transporters such as OATP1B1 and possibly efflux transporters, slightly raising fluvastatin levels.
What to do
No dose change is generally required. Advise patients to report unexplained muscle pain or weakness and check creatine kinase if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluvastatin and Ranolazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Ranolazine?
MediHelp rates the interaction as minor. Fluvastatin and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine may raise statin exposure through transporter effects, which could increase the risk of muscle toxicity. Fluvastatin is mainly metabolized by CYP2C9, so the effect is probably small.
How serious is the interaction between Fluvastatin and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Advise patients to report unexplained muscle pain or weakness and check creatine kinase if symptoms occur.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
