Drug interactions
Fluvastatin + Stiripentol
Severity: Moderate
Fluvastatin and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits BCRP and may increase fluvastatin exposure. This could increase dose-dependent statin adverse effects such as myopathy.
What this interaction means in plain words
Fluvastatin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits BCRP-mediated efflux of fluvastatin; it may also inhibit CYP2C9.
What to do
Monitor for muscle symptoms and reduce the fluvastatin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Fluvastatin with Stiripentol?
MediHelp rates the interaction as moderate. Fluvastatin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits BCRP and may increase fluvastatin exposure. This could increase dose-dependent statin adverse effects such as myopathy.
How serious is the interaction between Fluvastatin and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and reduce the fluvastatin dose if adverse effects occur.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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