Drug interactions
Fluvastatin + Vadadustat
Severity: Moderate
Fluvastatin and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP and increased exposure of BCRP substrate statins in studies. Fluvastatin levels may rise, increasing risk of dose-related muscle effects.
What this interaction means in plain words
Fluvastatin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of intestinal BCRP efflux by vadadustat increases fluvastatin absorption.
What to do
Monitor for muscle symptoms and consider reducing fluvastatin dose, as advised in vadadustat labeling. Check creatine kinase if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluvastatin and Vadadustat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Fluvastatin with Vadadustat?
MediHelp rates the interaction as moderate. Fluvastatin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits BCRP and increased exposure of BCRP substrate statins in studies. Fluvastatin levels may rise, increasing risk of dose-related muscle effects.
How serious is the interaction between Fluvastatin and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and consider reducing fluvastatin dose, as advised in vadadustat labeling. Check creatine kinase if symptoms appear.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
