Drug interactions
Fluvoxamine + Imatinib
Severity: Minor
Fluvoxamine and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6, but fluvoxamine is cleared by multiple pathways and is only partly dependent on CYP2D6, so a meaningful rise in fluvoxamine exposure is unlikely. Overlapping adverse effects such as nausea may occur.
What this interaction means in plain words
Fluvoxamine and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Imatinib belongs to Oncology.
Why it happens
Weak inhibition of CYP2D6 by imatinib, which is a minor pathway for fluvoxamine.
What to do
No dose adjustment is usually needed. Monitor for fluvoxamine adverse effects such as nausea and drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Fluvoxamine with Imatinib?
MediHelp rates the interaction as minor. Fluvoxamine and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imatinib inhibits CYP2D6, but fluvoxamine is cleared by multiple pathways and is only partly dependent on CYP2D6, so a meaningful rise in fluvoxamine exposure is unlikely. Overlapping adverse effects such as nausea may occur.
How serious is the interaction between Fluvoxamine and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for fluvoxamine adverse effects such as nausea and drowsiness.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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