Drug interactions
Fluvoxamine + Isavuconazonium
Severity: Minor
Fluvoxamine and Isavuconazonium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active moiety, is a CYP3A4 substrate, and fluvoxamine is only a weak to moderate CYP3A4 inhibitor. Increases in isavuconazole exposure are expected to be modest.
What this interaction means in plain words
Fluvoxamine and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Isavuconazonium belongs to Anti Fungals.
Why it happens
Weak inhibition of CYP3A4 metabolism of isavuconazole by fluvoxamine.
What to do
No dose change is usually required; monitor for isavuconazole adverse effects such as hepatic enzyme elevations and gastrointestinal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Isavuconazonium?
MediHelp rates the interaction as minor. Fluvoxamine and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole, the active moiety, is a CYP3A4 substrate, and fluvoxamine is only a weak to moderate CYP3A4 inhibitor. Increases in isavuconazole exposure are expected to be modest.
How serious is the interaction between Fluvoxamine and Isavuconazonium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; monitor for isavuconazole adverse effects such as hepatic enzyme elevations and gastrointestinal symptoms.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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