Drug interactions
Fluvoxamine + Lemborexant
Severity: Major
Fluvoxamine and Lemborexant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine, a moderate CYP3A4 inhibitor, raises lemborexant exposure, which increases next-day somnolence and impaired performance. Both agents also add to CNS depression.
What this interaction means in plain words
Fluvoxamine and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvoxamine belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by fluvoxamine increases lemborexant levels, with additive CNS depression.
What to do
Avoid the combination where possible; if used, do not exceed the lemborexant dose recommended with moderate CYP3A inhibitors and counsel on next-day impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Fluvoxamine with Lemborexant?
MediHelp rates the interaction as major. Fluvoxamine and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluvoxamine, a moderate CYP3A4 inhibitor, raises lemborexant exposure, which increases next-day somnolence and impaired performance. Both agents also add to CNS depression.
How serious is the interaction between Fluvoxamine and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, do not exceed the lemborexant dose recommended with moderate CYP3A inhibitors and counsel on next-day impairment.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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