Drug interactions
Fluvoxamine + Leniolisib
Severity: Minor
Fluvoxamine and Leniolisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib is a weak CYP1A2 inhibitor, and fluvoxamine is itself a CYP1A2 substrate but is mainly cleared by other pathways. The effect on fluvoxamine exposure is expected to be small, and leniolisib labeling cautions mainly about narrow therapeutic index CYP1A2 substrates such as theophylline and tizanidine.
What this interaction means in plain words
Fluvoxamine and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Leniolisib belongs to Miscellaneous.
Why it happens
Weak inhibition of CYP1A2 by leniolisib may slightly reduce fluvoxamine clearance.
What to do
No routine adjustment is needed; monitor for increased fluvoxamine adverse effects such as nausea or sedation if symptoms emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Fluvoxamine with Leniolisib?
MediHelp rates the interaction as minor. Fluvoxamine and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib is a weak CYP1A2 inhibitor, and fluvoxamine is itself a CYP1A2 substrate but is mainly cleared by other pathways. The effect on fluvoxamine exposure is expected to be small, and leniolisib labeling cautions mainly about narrow therapeutic index CYP1A2 substrates such as theophylline and tizanidine.
How serious is the interaction between Fluvoxamine and Leniolisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for increased fluvoxamine adverse effects such as nausea or sedation if symptoms emerge.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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