Drug interactions
Fluvoxamine + Lurbinectedin
Severity: Moderate
Fluvoxamine and Lurbinectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurbinectedin is metabolized mainly by CYP3A4, and inhibitors increase its exposure, which can worsen myelosuppression and hepatotoxicity. Fluvoxamine is a weak to moderate CYP3A4 inhibitor, so the effect is likely smaller than with strong inhibitors but still relevant.
What this interaction means in plain words
Fluvoxamine and Lurbinectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Lurbinectedin belongs to Oncology.
Why it happens
Fluvoxamine inhibits CYP3A4, reducing lurbinectedin metabolism.
What to do
Consider an alternative antidepressant; if coadministered, monitor blood counts and liver tests closely and reduce the lurbinectedin dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluvoxamine and Lurbinectedin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Fluvoxamine with Lurbinectedin?
MediHelp rates the interaction as moderate. Fluvoxamine and Lurbinectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurbinectedin is metabolized mainly by CYP3A4, and inhibitors increase its exposure, which can worsen myelosuppression and hepatotoxicity. Fluvoxamine is a weak to moderate CYP3A4 inhibitor, so the effect is likely smaller than with strong inhibitors but still relevant.
How serious is the interaction between Fluvoxamine and Lurbinectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antidepressant; if coadministered, monitor blood counts and liver tests closely and reduce the lurbinectedin dose if toxicity occurs.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
