Drug interactions
Fluvoxamine + Maprotiline
Severity: Major
Fluvoxamine and Maprotiline: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits several CYP enzymes including CYP2D6 and CYP1A2 and can raise maprotiline levels, increasing seizure and cardiac risk. The two drugs also have additive serotonergic effects that may cause serotonin syndrome.
What this interaction means in plain words
Fluvoxamine and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvoxamine belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
CYP inhibition by fluvoxamine reduces maprotiline metabolism, plus additive serotonergic effects.
What to do
Avoid if possible. If used together, lower the maprotiline dose, monitor drug levels and ECG, and watch for serotonin toxicity and seizures.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Maprotiline?
MediHelp rates the interaction as major. Fluvoxamine and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluvoxamine inhibits several CYP enzymes including CYP2D6 and CYP1A2 and can raise maprotiline levels, increasing seizure and cardiac risk. The two drugs also have additive serotonergic effects that may cause serotonin syndrome.
How serious is the interaction between Fluvoxamine and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used together, lower the maprotiline dose, monitor drug levels and ECG, and watch for serotonin toxicity and seizures.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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