Drug interactions
Fluvoxamine + Memantine-donepezil
Severity: Moderate
Fluvoxamine and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QT prolongation, so combined use may add to arrhythmia risk. Fluvoxamine inhibits CYP1A2, CYP2C19 and weakly CYP2D6/3A4, which may increase donepezil exposure somewhat.
What this interaction means in plain words
Fluvoxamine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QT prolongation with possible modest pharmacokinetic inhibition of donepezil metabolism.
What to do
Monitor ECG in patients with cardiac risk factors or electrolyte disturbances. Watch for bradycardia and gastrointestinal cholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Memantine-donepezil?
MediHelp rates the interaction as moderate. Fluvoxamine and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with QT prolongation, so combined use may add to arrhythmia risk. Fluvoxamine inhibits CYP1A2, CYP2C19 and weakly CYP2D6/3A4, which may increase donepezil exposure somewhat.
How serious is the interaction between Fluvoxamine and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors or electrolyte disturbances. Watch for bradycardia and gastrointestinal cholinergic effects.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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