Drug interactions
Fluvoxamine + Naldemedine
Severity: Minor
Fluvoxamine and Naldemedine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine is a weak to moderate CYP3A4 inhibitor and may raise naldemedine exposure. Higher naldemedine levels could increase gastrointestinal adverse effects such as abdominal pain and diarrhea, and in some cases opioid withdrawal-like symptoms.
What this interaction means in plain words
Fluvoxamine and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP3A4-mediated metabolism of naldemedine by fluvoxamine.
What to do
No dose change is usually needed; monitor for diarrhea, abdominal pain and opioid withdrawal symptoms, and reduce or stop naldemedine if they become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Fluvoxamine with Naldemedine?
MediHelp rates the interaction as minor. Fluvoxamine and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine is a weak to moderate CYP3A4 inhibitor and may raise naldemedine exposure. Higher naldemedine levels could increase gastrointestinal adverse effects such as abdominal pain and diarrhea, and in some cases opioid withdrawal-like symptoms.
How serious is the interaction between Fluvoxamine and Naldemedine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for diarrhea, abdominal pain and opioid withdrawal symptoms, and reduce or stop naldemedine if they become troublesome.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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