Drug interactions
Fluvoxamine + Naratriptan
Severity: Moderate
Fluvoxamine and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with a triptan can add serotonergic stimulation and rarely lead to serotonin syndrome. The risk is low in practice, and naratriptan is not heavily metabolized by the enzymes fluvoxamine inhibits.
What this interaction means in plain words
Fluvoxamine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effect from 5-HT1B/1D agonism plus serotonin reuptake inhibition.
What to do
Counsel on symptoms of serotonin syndrome and monitor, especially when starting the combination or raising doses. Stop naratriptan and treat promptly if symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Naratriptan?
MediHelp rates the interaction as moderate. Fluvoxamine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SSRI with a triptan can add serotonergic stimulation and rarely lead to serotonin syndrome. The risk is low in practice, and naratriptan is not heavily metabolized by the enzymes fluvoxamine inhibits.
How serious is the interaction between Fluvoxamine and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on symptoms of serotonin syndrome and monitor, especially when starting the combination or raising doses. Stop naratriptan and treat promptly if symptoms emerge.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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