Drug interactions
Fluvoxamine + Nicardipine
Severity: Moderate
Fluvoxamine and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits CYP3A4 and CYP2C19 and may raise nicardipine concentrations. This can cause hypotension, flushing, headache and edema.
What this interaction means in plain words
Fluvoxamine and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Fluvoxamine inhibits CYP3A4 metabolism of nicardipine.
What to do
Monitor blood pressure and heart rate when fluvoxamine is started. Reduce the nicardipine dose if hypotension or marked adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Nicardipine?
MediHelp rates the interaction as moderate. Fluvoxamine and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine inhibits CYP3A4 and CYP2C19 and may raise nicardipine concentrations. This can cause hypotension, flushing, headache and edema.
How serious is the interaction between Fluvoxamine and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when fluvoxamine is started. Reduce the nicardipine dose if hypotension or marked adverse effects occur.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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