Drug interactions
Fluvoxamine + Oliceridine
Severity: Major
Fluvoxamine and Oliceridine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is metabolized by CYP3A4 and CYP2D6, and fluvoxamine inhibits CYP3A4 and to a lesser extent CYP2D6, which can raise oliceridine levels and increase sedation and respiratory depression. Both drugs also affect serotonergic pathways, so serotonin syndrome is a theoretical concern. Stopping fluvoxamine can reduce opioid effect.
What this interaction means in plain words
Fluvoxamine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvoxamine belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
CYP3A4 and CYP2D6 inhibition raises oliceridine exposure, with additive serotonergic and CNS depressant effects.
What to do
Use lower or less frequent oliceridine doses and monitor closely for respiratory depression and sedation. Watch for serotonin toxicity and reassess dosing if fluvoxamine is started or stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Fluvoxamine with Oliceridine?
MediHelp rates the interaction as major. Fluvoxamine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oliceridine is metabolized by CYP3A4 and CYP2D6, and fluvoxamine inhibits CYP3A4 and to a lesser extent CYP2D6, which can raise oliceridine levels and increase sedation and respiratory depression. Both drugs also affect serotonergic pathways, so serotonin syndrome is a theoretical concern. Stopping fluvoxamine can reduce opioid effect.
How serious is the interaction between Fluvoxamine and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower or less frequent oliceridine doses and monitor closely for respiratory depression and sedation. Watch for serotonin toxicity and reassess dosing if fluvoxamine is started or stopped.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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