Drug interactions
Fluvoxamine + Pexidartinib
Severity: Major
Fluvoxamine and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is cleared via CYP3A4 and UGT1A4, and inhibitors raise exposure, increasing the risk of serious hepatotoxicity. Fluvoxamine is a weak to moderate CYP3A4 inhibitor.
What this interaction means in plain words
Fluvoxamine and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvoxamine belongs to Central Nervous System; Pexidartinib belongs to Oncology.
Why it happens
Fluvoxamine inhibits CYP3A4, reducing pexidartinib clearance.
What to do
Avoid if possible; if unavoidable, reduce the pexidartinib dose per labeling and monitor liver tests closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluvoxamine and Pexidartinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Fluvoxamine with Pexidartinib?
MediHelp rates the interaction as major. Fluvoxamine and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib is cleared via CYP3A4 and UGT1A4, and inhibitors raise exposure, increasing the risk of serious hepatotoxicity. Fluvoxamine is a weak to moderate CYP3A4 inhibitor.
How serious is the interaction between Fluvoxamine and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if unavoidable, reduce the pexidartinib dose per labeling and monitor liver tests closely.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
