Drug interactions
Fluvoxamine + Primaquine
Severity: Moderate
Fluvoxamine and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QT interval and together could increase the risk of arrhythmia. Fluvoxamine also inhibits CYP1A2 and CYP2C19, which may influence primaquine exposure.
What this interaction means in plain words
Fluvoxamine and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Primaquine belongs to Anti Parasitic.
Why it happens
Additive QTc prolongation; fluvoxamine may inhibit primaquine metabolism via CYP1A2.
What to do
Obtain a baseline ECG and correct electrolytes, then monitor the ECG and watch for primaquine adverse effects such as hemolysis or methemoglobinemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Primaquine?
MediHelp rates the interaction as moderate. Fluvoxamine and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may prolong the QT interval and together could increase the risk of arrhythmia. Fluvoxamine also inhibits CYP1A2 and CYP2C19, which may influence primaquine exposure.
How serious is the interaction between Fluvoxamine and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes, then monitor the ECG and watch for primaquine adverse effects such as hemolysis or methemoglobinemia.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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