Drug interactions
Fluvoxamine + Quetiapine
Severity: Moderate
Fluvoxamine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is cleared mainly by CYP3A4, and fluvoxamine can modestly increase its exposure. This may increase sedation, orthostatic hypotension and QT effects.
What this interaction means in plain words
Fluvoxamine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by fluvoxamine reduces quetiapine clearance.
What to do
Monitor for sedation, hypotension and QTc changes, and lower the quetiapine dose if adverse effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Fluvoxamine with Quetiapine?
MediHelp rates the interaction as moderate. Fluvoxamine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is cleared mainly by CYP3A4, and fluvoxamine can modestly increase its exposure. This may increase sedation, orthostatic hypotension and QT effects.
How serious is the interaction between Fluvoxamine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, hypotension and QTc changes, and lower the quetiapine dose if adverse effects arise.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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