Drug interactions
Fluvoxamine + Roflumilast
Severity: Moderate
Fluvoxamine and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine strongly inhibits CYP1A2 and also inhibits CYP3A4 and CYP2C19, the pathways that clear roflumilast. Combined exposure can increase, raising the risk of adverse effects such as diarrhea, weight loss, insomnia, anxiety and headache.
What this interaction means in plain words
Fluvoxamine and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Roflumilast belongs to Respiratory.
Why it happens
Fluvoxamine inhibits CYP1A2, CYP2C19 and CYP3A4, reducing roflumilast clearance.
What to do
Monitor for roflumilast adverse effects, including weight loss and psychiatric symptoms, and consider a different antidepressant if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Roflumilast?
MediHelp rates the interaction as moderate. Fluvoxamine and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine strongly inhibits CYP1A2 and also inhibits CYP3A4 and CYP2C19, the pathways that clear roflumilast. Combined exposure can increase, raising the risk of adverse effects such as diarrhea, weight loss, insomnia, anxiety and headache.
How serious is the interaction between Fluvoxamine and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for roflumilast adverse effects, including weight loss and psychiatric symptoms, and consider a different antidepressant if these occur.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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