Drug interactions
Fluvoxamine + Saxagliptin-metformin
Severity: Minor
Fluvoxamine and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine may enhance glucose lowering and has been linked to dysglycemia in patients on antidiabetic drugs. It is also a CYP inhibitor, but saxagliptin and metformin are not significantly affected via CYP1A2 or CYP2C19.
What this interaction means in plain words
Fluvoxamine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Possible SSRI effects on insulin sensitivity; the mechanism is not well established.
What to do
Monitor blood glucose when starting or stopping fluvoxamine and adjust antidiabetic doses if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Fluvoxamine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine may enhance glucose lowering and has been linked to dysglycemia in patients on antidiabetic drugs. It is also a CYP inhibitor, but saxagliptin and metformin are not significantly affected via CYP1A2 or CYP2C19.
How serious is the interaction between Fluvoxamine and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fluvoxamine and adjust antidiabetic doses if needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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