Drug interactions
Fluvoxamine + Sulindac
Severity: Moderate
Fluvoxamine and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine, like other SSRIs, impairs platelet function, and combined with an NSAID this increases the risk of gastrointestinal and other bleeding. Risk is higher in the elderly and in patients with a history of ulcer disease.
What this interaction means in plain words
Fluvoxamine and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Sulindac belongs to Musculoskeletal.
Why it happens
SSRI-induced platelet serotonin depletion adds to NSAID-mediated platelet inhibition and mucosal injury.
What to do
Consider gastroprotection with a proton pump inhibitor in high-risk patients and monitor for signs of bleeding or falling hemoglobin. Use an alternative analgesic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Sulindac?
MediHelp rates the interaction as moderate. Fluvoxamine and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine, like other SSRIs, impairs platelet function, and combined with an NSAID this increases the risk of gastrointestinal and other bleeding. Risk is higher in the elderly and in patients with a history of ulcer disease.
How serious is the interaction between Fluvoxamine and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor in high-risk patients and monitor for signs of bleeding or falling hemoglobin. Use an alternative analgesic if possible.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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