Drug interactions
Fluvoxamine + Sumatriptan
Severity: Moderate
Fluvoxamine and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Co-administration of an SSRI and sumatriptan may add serotonergic stimulation, and serotonin syndrome has been reported although it is uncommon. The combination is often used in practice when benefits outweigh risks.
What this interaction means in plain words
Fluvoxamine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effect from 5-HT1B/1D agonism plus serotonin reuptake inhibition.
What to do
Counsel on symptoms such as agitation, tremor, sweating, diarrhea and hyperthermia, and monitor at initiation or dose increases. Stop the triptan and treat if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Sumatriptan?
MediHelp rates the interaction as moderate. Fluvoxamine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Co-administration of an SSRI and sumatriptan may add serotonergic stimulation, and serotonin syndrome has been reported although it is uncommon. The combination is often used in practice when benefits outweigh risks.
How serious is the interaction between Fluvoxamine and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on symptoms such as agitation, tremor, sweating, diarrhea and hyperthermia, and monitor at initiation or dose increases. Stop the triptan and treat if serotonin syndrome is suspected.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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