Drug interactions
Fluvoxamine + Terbinafine
Severity: Minor
Fluvoxamine and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbinafine is a strong CYP2D6 inhibitor, but fluvoxamine is metabolized mainly by CYP2D6 only to a limited extent, so exposure rises modestly. Fluvoxamine inhibits CYP1A2 and CYP2C19 and may somewhat raise terbinafine levels, with minor expected clinical effect.
What this interaction means in plain words
Fluvoxamine and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Terbinafine belongs to Anti Fungals.
Why it happens
Terbinafine inhibits CYP2D6 and fluvoxamine inhibits CYP1A2 and CYP2C19, both contributing to terbinafine and fluvoxamine clearance.
What to do
No routine adjustment is needed; monitor for fluvoxamine adverse effects such as nausea and sedation and for terbinafine gastrointestinal effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Terbinafine?
MediHelp rates the interaction as minor. Fluvoxamine and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Terbinafine is a strong CYP2D6 inhibitor, but fluvoxamine is metabolized mainly by CYP2D6 only to a limited extent, so exposure rises modestly. Fluvoxamine inhibits CYP1A2 and CYP2C19 and may somewhat raise terbinafine levels, with minor expected clinical effect.
How serious is the interaction between Fluvoxamine and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for fluvoxamine adverse effects such as nausea and sedation and for terbinafine gastrointestinal effects.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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