Drug interactions
Fluvoxamine + Tetrabenazine
Severity: Moderate
Fluvoxamine and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine prolongs the QT interval and fluvoxamine has some QT-prolonging potential, so the combination may increase arrhythmia risk. Fluvoxamine also inhibits CYP2D6 weakly, which may modestly raise levels of the active tetrabenazine metabolites.
What this interaction means in plain words
Fluvoxamine and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus fluvoxamine's inhibition of CYP2D6-mediated metabolism of tetrabenazine's active metabolites.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes, correcting potassium and magnesium. Limit the tetrabenazine dose according to labeling and consider another antidepressant if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Tetrabenazine?
MediHelp rates the interaction as moderate. Fluvoxamine and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetrabenazine prolongs the QT interval and fluvoxamine has some QT-prolonging potential, so the combination may increase arrhythmia risk. Fluvoxamine also inhibits CYP2D6 weakly, which may modestly raise levels of the active tetrabenazine metabolites.
How serious is the interaction between Fluvoxamine and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes, correcting potassium and magnesium. Limit the tetrabenazine dose according to labeling and consider another antidepressant if QTc lengthens.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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