Drug interactions
Fluvoxamine + Tinidazole
Severity: Minor
Fluvoxamine and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine is a potent CYP1A2 and CYP2C19 inhibitor with weaker CYP3A4 inhibition, so it could modestly raise tinidazole exposure. Tinidazole has a wide therapeutic margin and short courses are typical, so clinical consequences are expected to be small. Additive gastrointestinal side effects such as nausea are possible.
What this interaction means in plain words
Fluvoxamine and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Tinidazole belongs to Anti Parasitic.
Why it happens
Weak inhibition of CYP3A4 by fluvoxamine may slightly reduce tinidazole metabolism.
What to do
No dose change is usually needed; counsel the patient about nausea and other adverse effects during the tinidazole course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Tinidazole?
MediHelp rates the interaction as minor. Fluvoxamine and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine is a potent CYP1A2 and CYP2C19 inhibitor with weaker CYP3A4 inhibition, so it could modestly raise tinidazole exposure. Tinidazole has a wide therapeutic margin and short courses are typical, so clinical consequences are expected to be small. Additive gastrointestinal side effects such as nausea are possible.
How serious is the interaction between Fluvoxamine and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; counsel the patient about nausea and other adverse effects during the tinidazole course.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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