Drug interactions
Fluvoxamine + Verapamil
Severity: Moderate
Fluvoxamine and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits several CYP enzymes including CYP3A4 and may raise verapamil concentrations. This can cause excessive bradycardia, AV block and hypotension.
What this interaction means in plain words
Fluvoxamine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Fluvoxamine inhibits CYP3A4 (and CYP1A2, 2C19), reducing verapamil clearance.
What to do
Monitor heart rate, ECG PR interval and blood pressure when starting or stopping fluvoxamine. Reduce the verapamil dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Verapamil?
MediHelp rates the interaction as moderate. Fluvoxamine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine inhibits several CYP enzymes including CYP3A4 and may raise verapamil concentrations. This can cause excessive bradycardia, AV block and hypotension.
How serious is the interaction between Fluvoxamine and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG PR interval and blood pressure when starting or stopping fluvoxamine. Reduce the verapamil dose if bradycardia or hypotension develops.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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